Source distribution of neuromagnetic slow wave activity in schizophrenic and depressive patients.
نویسندگان
چکیده
OBJECTIVE Focal slow waves in the delta and theta frequency range frequently appear in psychopathological conditions. Due to their focal nature they can be localized by dipole modeling. We previously reported regional clustering of slow waves in temporal and parietal cortex of schizophrenic patients whereas such activity is largely absent in normals. Here we examine, to what extent distribution of slow wave generators differentiates schizophrenic from depressive syndromes. METHODS The regional densities of generators of focal slow waves were determined during resting conditions in patients with DSM-IV diagnoses of schizophrenia (N=25) and depression (N=27) and in 18 healthy controls. RESULTS Schizophrenic patients demonstrated accentuated temporal and parietal delta and theta dipole clustering, when compared to both the control and the depressive sample. In contrast, depressive patients had reduced frontal and prefrontal delta and theta dipole density relative to both schizophrenics and controls. This pattern was not related to age. Men generally displayed somewhat higher slow wave activity than women. For the areas of most pronounced slow wave deviances activity within each group was related to symptom scores: higher left-temporal slow wave activity was associated with hallucinations in schizophrenics, suppression of left-prefrontal slow wave activity correlated with depression scores. CONCLUSIONS Results suggest that slow wave distribution may assist in differentially diagnosing psychopathological conditions.
منابع مشابه
Source distribution of neuromagnetic slow waves and MEG-delta activity in schizophrenic patients.
BACKGROUND Schizophrenic patients exhibit more activity in the electroencephalographic delta and theta frequency range than do control subjects. Using magnetic source imaging (MSI) our study aimed to explore this phenomenon in the magnetoencephalogram (MEG), the distribution of its sources, and associations between symptom profiles and sources of low-frequency activity in the brain. METHODS W...
متن کاملSource distribution of neuromagnetic slow wave and alpha activity in depressive patients: therapy-dependent changes. 2005
متن کامل
Source distribution of neuromagnetic slow-wave activity in schizophrenic patients--effects of activation.
When slow waves in the EEG delta and theta frequency range appear in the waking state, they may indicate pathological conditions including psychopathology. The generators of focal slow waves can be mapped using magnetic source imaging. The resulting brain maps may possibly characterize dysfunctional brain areas. The present study examined the stability of the density and distribution of MEG slo...
متن کاملThe Frequency Distribution of Chief Complaints in Patients with Major Depressive Disorder Referring to Psychiatric Clinics in Kerman
Introduction: Physical symptoms associated with depression and common psychiatric disorders sometimes lead to the misdiagnosis of depressive disorders. The aim of this study was to determine the frequency distribution of different chief complaints in patients with major depressive disorder referring to psychiatric clinics according to their demographic characteristics and source of referral. Me...
متن کاملمقایسه فعالیت امواج نواحی خلفی مغز در بیماران اسکیزوفرنیا و افراد سالم
Background & Aims: Schizophrenia is characterized by a broad range of unusual behaviors that cause profound disruption in the lives of the patients suffering from the condition. individuals with schizophrenia show dysfunction within brain lobes. The aim of this research was to compare brain posterior areas' wave activities in the schizophrenic patient with a healthy group. Materials & Metho...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
دوره 114 11 شماره
صفحات -
تاریخ انتشار 2003